Verbascoside, also known as Acteoside or Kusaginin, is a type of active component extracted from Cistanche tubulosa, Rehmannia Glutinosa Libosch and Lemon Verbena, is one of the most powerful free radical scavengers exhibiting a wide biological activity. Verbascoside is a disaccharide ester that contains a rhamnose unit linked to a glucose molecule via a bridge. The compound is produced in plant organs (especially the roots and leaves) and in vitro plant culture systems. This disaccharide possesses many health benefits, including neuroprotection and anti-inflammatory activity. Recent studies have also demonstrated its antioxidant effects, while there some further studies are needed to determine its biological activity.
Structure of verbascoside
Sources of Verbascoside
Verbascoside can be found in various plant sources, including olive leaves, plantago species, Verbascum species, Rehmannia glutinosa, and citstanche species. Here are the top 5 plants containing Verbascoside:
Benefits of Verbascoside
Antioxidant Activity
Research has shown that verbascoside can modify mitochondrial activity. The compound protects DNA from ROS and prevents the opening of the mitochondrial permeability transition pore, which may alter cellular and mitochondrial dynamics. The compound is also known to modify the activity of PERK. This information could open new avenues for developing treatments to reduce oxidative stress and inflammation.
Moreover, verbascoside has proven to be a natural antioxidant. It modulates redox homeostasis in btc3 cells. Several studies on the inhibitory activity of verbascoside in elastase were conducted to determine the compound’s effects on this enzyme. In vitro, the drug inhibits p.nitroalinine, which is responsible for many inflammatory disorders and aging. It has also been shown to inhibit the activity of the elastase 5a-reductase, which regulates androgen homeostasis in human skin.
Anti-inflammatory Properties
Verbascoside is a potent compound for other inflammatory diseases. It inhibits the overproduction of apoptotic cells, a crucial process in diabetes. It increases insulin content and improves B-cell function. In addition, it also reduces the bacterial burden. Its use in chemotherapy and other drugs is still in the early stages of development, but it is an effective treatment for many bacterial infections.
In a clinical trial, Verbascoside was found to significantly alleviate the symptoms of infected mice and reduce bacterial burden. The drug’s virulence was also significantly reduced, and no significant changes in the body parameters were noted during 21 days of oral administration. Its effectiveness in treating gas gangrene is likely to be further evaluated, as well as its ability to reduce the inflammation and mortality associated with these infections. Despite its positive effects, many issues need to be resolved before verbascoside can be safely used in human disease. Moreover, clinical studies on animals are insufficient.
Neuroprotective Effects
Verbascoside offers remarkable support for brain health and cognitive function, acting as a protective shield for your brain cells. Research suggests that verbascoside can potentially slow down age-related mental decline, support memory function, and protect against neurodegenerative processes. It helps defend the neurons against daily damage caused by stress, aging, and environmental factors. This powerful compound works by neutralizing harmful free radicals, reducing inflammation, and supporting the overall resilience of brain cells.
Applications of verbascoside
Brain Health Products
One of the most exciting applications of verbascoside lies in neuroprotective drugs. Research suggests that it may help protect neural cells and support cognitive function. Supplement manufacturers are incorporating verbascoside into products designed to support memory, brain health and promote overall cognitive wellness.
Skincare Products
The cosmetic industry has embraced verbascoside for its remarkable anti-inflammatory properties. The compound’s natural properties help maintain skin health while fighting free radicals that contribute to premature aging and support skin barrier function.
Wellness supplements
Modern research has unveiled verbascoside’s potential in supporting healthy inflammatory responses. This has led to its inclusion in joint health supplements, recovery formulations, and immune system support products. In addition, athletes and fitness enthusiasts are discovering verbascoside’s benefits for post-exercise recovery, cellular protection during intense training, and endurance enhancement.
In Conclusion
Verbascoside represents a perfect blend of nature’s wisdom and modern science. Its excellent power continues to expand as research unveils new properties and benefits. From brain health to skin protection, and athletic performance to healthy aging, verbascoside stands as a testament to the power of natural compounds in modern health and wellness applications.
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