Fisetin is a common dietary flavonoid found in many fruits and vegetables. Fisetin is beneficial for our health because it inhibits autophagy, slows down senescence, and may even prevent age-related diseases. You may be wondering: What foods contain fisetin? Well, you are not alone!  Let’s look at some of the best sources of this antioxidant. Trace amounts of fisetin can also be found in some fruits and vegetables. Based on the available research, strawberries have the most fisetin, followed by apples. The amount of Fisetin in strawberries is about five times that in apples, and more than 30 times that in mangoes, kiwis, grapes, tomatoes, Onions, cucumbers and nuts.

Fisetin is naturally occurring in a number of fruits and vegetables and has a high probability of applying to humans. However, the amount of natural Fisetin in these foods is far less than that of dietary supplements. Modern technology derived natural fisetin from the leaves, stems, roots, and branches from sumac family plants such as Cotinus coggygria (Smoke tree), lacquer tree, Rhus semialata Murray, Euphorbia emblica and Buxaceae plants, and then obtained after extraction, purification and drying, which is the primary source of fisetin on the market. Do you know what’s the benefits of fisetin?

Reduces senescence

A recent study has shown that a plant metabolite called fisetin can reduce the senescence markers found in human and mouse cells.  This means it could have a wide range of health benefits. These compounds scavenge free radicals, which are unstable forms of oxygen that can damage lipids, carbohydrates, and nucleic acids. This imbalance in antioxidants and reactive oxygen species is known as oxidative stress. It is linked to conditions including diabetes, cardiovascular disease, obesity, and immunological disorders, as well as aging.

Recent research suggests that fisetin powder may help reduce the risk of age-related diseases, including diabetes and cardiovascular disease. This antioxidant also works to reduce the lipid content in blood, which may contribute to the development of metabolic disorders such as diabetes and insulin resistance. In addition, it suppresses the NF-kB pathway, which is thought to play a key role in aging and age-related diseases.

Cotinus coggygria


Fisetin has shown some promise as an anti-inflammatory drug because it acts as a potent antioxidant. Inflammation results from prolonged immune responses, which can lead to diseases like cardiovascular disease, cancer, and neurological abnormalities. Consequently, treating inflammation is important for reducing the risk of developing these chronic conditions. Scientists have investigated the effects of fisetin as an antioxidant and as a cancer-fighting drug.

Fisetin is known to induce autophagy by regulating the levels of inflammatory cytokines and IL-1b. Among other things, fisetin inhibits inflammasomes, which are the primary initiators of autophagy. We used ELISA assays to detect the levels of IL-1b and IL-18 in mouse serum. Fisetin inhibited inflammasomes and facilitated the fusion of autophagosomes and lysosomes.


The plant has long offered cures for many ailments, including cancer. There is an increasing body of evidence that the antioxidant protein Fisetin is anti-tumoriogenic and inhibits the activation of HMC-1 mast cells. Fisetin inhibits HUVEC activation through inhibition of nuclear factor kappa B and MAPK. Its potential as an anti-inflammatory agent is also well recognized.


In a study, researchers found that fisetin promoted mitophagy, facilitated the clearance of damaged mitochondria, and reduced the levels of ROS and IL-1b in the CNS. They also observed that fisetin inhibited the release of IL-1b into the CNS, a marker of severe neuroinflammation. Fisetin also significantly improved the cognitive dysfunction of rats with SAE. It has the potential to cross the blood-brain barrier and may help maintain neuronal function even in the face of factors leading to age-related declines in normal brain function. These findings suggest that fisetin has neuroprotective effects through inhibiting neuroinflammation and mitophagy.

Cardioprotective effects

Fisetin is an antioxidant with cardioprotective properties. Fisetin inhibits the production of ROS and may be a potential inhibitor of cell apoptosis. In addition, fisetin promotes cardiomyocyte maturation, has been found to have cardioprotective effects. Further research on fisetin and the cyclin-CDK complex will help understand its role in cardiomyocyte protection.

Some fisetin supplements are popular precisely because of their powerful antioxidant properties, which promote brain health. It can help maintain glutathione levels and mitochondrial function in the presence of oxidative stress. Fisetin is also shown to have beneficial effects on bone health, and its use could help treat osteoporosis. Smoke trees are also good for refining essential oil, which is said to be popular with consumers in Greece because of its light taste.

Ye Tao