Oat Beta Glucan And Immune System

Beta-glucan is a long chain of naturally occurring carbohydrates called polysaccharides found in yeast, fungi, bacteria and certain plants including seaweed, such as barley and oats. Beta-glucan has been widely used as a dietary supplement, it has hardly been advertised compared to other more popular supplements, but there is reason to believe it may help stimulate the immune system and protect against everything from infectious diseases to cancer.

Yeast-derived Beta Glucan

The basis of many of the benefits of beta-glucan may be its ability to enhance the innate immune system, a mechanism first proposed by Dr. Rolf Seljelid, Emeritus Professor at the University of Troms in Norway. In the 1980s, he noticed that sea urchins had a unique ability to survive and reproduce in heavily polluted waters, including those in hospital runoff contaminated with bacteria and viruses. It turned out to be β -glucan.

Oats contain the most beta-glucan of all grains, so we’re serving more oat beta-glucan, which is also the main dietary fiber in oat bran and has important physiological functions. β -glucan exists in the cell wall of the oat milk embryo and aleurone layer and is enriched in the subaleurone layer of grain. It is mainly a kind of undigestible β -d-glucan formed by many monosaccharides through β- (1,3) and β- (1,4) glycosidic links. This special structure also makes the oat glucan have special physiological functions.

How does beta-glucan help the immune system?

It is widely accepted that maintaining a healthy immune system is important for maintaining good health, but the immune system is one of the most complex systems in the body and occasionally fails to defend against disease-causing microbes, which succeed in invading and causing disease. So is it possible to interfere with the invasion process to make your immune system stronger? Recent studies have also shown that beta-glucan can support a range of health claims, from boosting immunity to lowering cholesterol to promoting wound healing and protecting bone marrow.
According to the Texas Marathon study, “marathon participants who took beta-glucan had a 40 percent reduction in upper respiratory infection (URI), a significant 42 percent increase in activity indicators and a 38% reduction in fatigue.” After β -glucan binds, cells react by producing various molecules that then stimulate other cell types. That’s why beta-glucan is so versatile because it affects so many cells involved in immunity and other responses.

It has long been thought that beta-glucan affects only cell types of the immune response. However, later studies have clearly shown that beta-glucan also stimulates antibody responses, meaning that it also has a direct effect on the humoral branch of the immune response. Based on these studies, beta-glucan is now being investigated in-depth as a potential vaccine.” Experts explain.

Studies have shown that beta-glucan can effectively activate macrophages, the basic cells of the immune system, which can improve immune defense against harmful bacteria and inflammatory factors. Macrophages can remove damaged skin components, produce epidermal growth factors, and further stimulate fibroblast proliferation. Beta-glucan also speeds keratinocyte migration and promotes the production of collagen and hyaluronic acid, which are essential for wound healing. In addition, β -glucan also promotes more cellular interstitial regeneration, which contributes to skin epidermal reconstruction, especially for sensitive skin repair.

Oats β -glucan has also been linked to the burgeoning market for prebiotics and dietary fiber. β -glucan, in combination with vitamin C, enhances the microbiome in the gastrointestinal tract and is currently being studied more for its effects on the body’s immune function. In the fields of cosmetics, nutrition and food industry, β -glucan will have a broader future.

Ye Tao